Bosentas Bosentan Tablets

Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure.

Bosentan is used to treat pulmonary arterial hypertension (PAH, high blood pressure in the vessels that carry blood to the lungs) in adults and children 3 years of age and older. Bosentan may improve the ability to exercise and slow the worsening of symptoms in patients with PAH

Bosentan works by competitively blocking endothelin-1 (ET-1) receptors (both ETA and ETB) in the pulmonary vasculature, preventing ET-1 from causing blood vessel constriction, smooth muscle cell proliferation, fibrosis, and inflammation. By antagonizing these effects, bosentan relaxes pulmonary arteries, lowers pulmonary pressure, decreases pulmonary vascular resistance, and increases blood supply to the lungs, thereby treating